MLK2 ist ein Gen, das durch das Symbol MAP3K10 kodiert wird. Im Allgemeinen auch bezeichnet als: Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST; MAP3K10; MST. MLK2 hat eine Masse von 103.69kDa und eine Aminosäurelänge von 954.
Wir bieten 2 MLK2proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Activates the JUN N-terminal pathway.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Gewebespezifität
Expressed in brain and skeletal muscle.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Posttranslationale Modifikation
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
