PDGF AA ist ein Gen, das durch das Symbol PDGFA kodiert wird. Im Allgemeinen auch bezeichnet als: Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; PDGFA; PDGF1. PDGF AA hat eine Masse von 24.04kDa und eine Aminosäurelänge von 211.
Wir bieten 4 PDGF AAproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.
Sequenzähnlichkeiten
Belongs to the PDGF/VEGF growth factor family.
Zellort
Secreted.
Released by platelets upon wounding.
