Phospholipase A2 X ist ein Gen, das durch das Symbol PLA2G10 kodiert wird. Im Allgemeinen auch bezeichnet als: Group 10 secretory phospholipase A2; Group X secretory phospholipase A2; GX sPLA2; Phosphatidylcholine 2-acylhydrolase 10; PLA2G10. Phospholipase A2 X hat eine Masse von 18.15kDa und eine Aminosäurelänge von 165.
Wir bieten 1 Phospholipase A2 Xproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Entrez Zusammenfassung
This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism.
Gewebespezifität
Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.
Sequenzähnlichkeiten
Belongs to the phospholipase A2 family.
