TNFSF18 ist ein Gen, das durch das Symbol TNFSF18 kodiert wird. Es ist auch bekannt als: Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; GITRL; TL6. TNFSF18 hat eine Masse von 22.72kDa und eine Aminosäurelänge von 199.
Wir bieten 3 TNFSF18proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Gewebespezifität
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Sequenzähnlichkeiten
Belongs to the tumor necrosis factor family.
