UBA2 ist ein Gen, das durch das Symbol UBA2 kodiert wird. Es ist auch bekannt als: SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; SAE2; UBLE1B. UBA2 hat eine Masse von 71.22kDa und eine Aminosäurelänge von 640.
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Gen- und Proteininformationen
UniProt Zusammenfassung
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Entrez Zusammenfassung
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
Sequenzähnlichkeiten
Belongs to the ubiquitin-activating E1 family.
Posttranslationale Modifikation
Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.
Zellort
Cytoplasm. Nucleus.
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
