Anti-Reelin Antikörper [RELN/4498] (A277582)

Anti-Reelin Antibody [RELN/4498]

Mouse monoclonal [RELN/4498] antibody to Reelin.

Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

ELISA, IP, IF, WB, IHC-P

IP: 1-2µg / 100-500µg proteins, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse, Rat

Recombinant fragment, around amino acids 1,796-2,115, of human Reelin protein. The exact sequence is proprietary.

Mouse

Monoclonal

RELN/4498

IgG2b

Protein A/G chromatography.

200 µg/ml

387.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Reelin Antibody [RELN/4498] - BSA and Azide free (A278170).

LIS2, PRO1598, Reeler, RELN, RELN_HUMAN, RL