Anti-Adiponectin Anticorps [D05-9C7] (A280201)

Anti-Adiponectin Antibody [D05-9C7]

Mouse monoclonal [D05-9C7] antibody to Adiponectin.

This antibody recognises adiponectin, also known as ACRP30, apM-1, ADIPOQ. Adiponectin is a fat-derived hormone which suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, and acts as a messenger to allow communication between adipose tissue and other organs. Adiponectin can elicit several downstream signaling events, including the insulin signaling pathway. Anti-diabetic, anti-inflammatory, and anti-atherogenic effects of adiponectin have been identified, and the protein sensitizes cells to insulin. Decreased adiponecin levels may play a role in development of type 2 diabetes, and therefore, adiponectin has been suggested as a potential therapeutic target for diabetes. The purified Mouse anti Human adiponectin antibody, clone D05-9C7 can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human adiponectin antibody, clone D02-7B10 (MCA6175B) as the detection antibody.

ELISA

ELISA: 1 µg/ml

Human

E. coli derived recombinant human adiponectin (Glu19-Asn244).

Mouse

Monoclonal

D05-9C7

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human adiponectin antibody, clone D05-9C7,recognizes adiponectin, also known as ACRP30, apM-1, ADIPOQ. Adiponectin is a fat-derived hormone which suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, and acts as a messenger to allow communication between adipose tissue and other organs (Wang and Scherer, 2016). Adiponectin can elicit several downstream signaling events, including the insulin signaling pathway. Anti-diabetic, anti-inflammatory, and anti-atherogenic effects of adiponectin have been identified, and the protein sensitizes cells to insulin. Decreased adiponecin levels may play a role in development of type 2 diabetes, and therefore, adiponectin has been suggested as a potential therapeutic target for diabetes (Achari and Jain 2017). The purified Mouse anti Human adiponectin antibody, clone D05-9C7 can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human adiponectin antibody, clone D02-7B10 (MCA6175B) as the detection antibody.

30 kDa adipocyte complement related protein, 30 kDa adipocyte complement-related protein, ACDC, ACRP30, Adipocyte, Adipocyte C1q and collagen domain containing protein, Adipocyte complement related 30 kDa protein, Adipocyte complement related protein of 30 kDa, Adipocyte complement-related 30 kDa protein, adipocyte-specific secretory protein, Adiponectin precursor, adiponectin, C1Q and collagen domain containing, Adipoq, Adipose most abundant gene transcript 1, Adipose most abundant gene transcript 1 protein, Adipose specific collagen like factor, ADIPO_HUMAN, ADIPQTL1, ADPN, APM 1, apM-1, APM1, C1q and collagen domain-containing protein, GBP28, Gelatin binding protein , Gelatin binding protein 28, Gelatin-binding protein