Anti-alpha Fodrin Anticorps [SPTAN1/3351] (A253220)

Name: Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free
Brand: Antibodies.com
SKU: A253220
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [SPTAN1/3351] de souris contre alpha Fodrin pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free

Description du produit

Mouse monoclonal [SPTAN1/3351] antibody to alpha Fodrin.

Spécificité

Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 2351-2475, of human SPTAN1 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

SPTAN1/3351

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Masse moléculaire

240 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-alpha Fodrin Antibody [SPTAN1/3351] (A250040).

Synonymes

(ALPHA)II-SPECTRIN, Alpha II Spectrin, Alpha-II spectrin, brain, EIEE5, FLJ17738, FLJ44613, Fodrin alpha chain, Fodrin, alpha, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin, Spectrin alpha chain, Spectrin alpha chain brain, Spectrin alpha non erythrocytic 1, Spectrin non erythroid alpha chain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spectrin, nonerythroid, alpha subunit, Spna2, SPTA 2, SPTA2, SPTA2_HUMAN, SPTAN 1, SPTAN1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Immunohistochemistry - Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free (A253220)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-alpha Fodrin Antibody [SPTAN1/3351].

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Figure 2: Immunohistochemistry - Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free (A253220)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human tonsil using Anti-alpha Fodrin Antibody [SPTAN1/3351].

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Figure 3: SDS-PAGE - Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free (A253220)

SDS-PAGE analysis of Anti-alpha Fodrin Antibody [SPTAN1/3351] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-alpha Fodrin Antibody [SPTAN1/3351] - BSA and Azide free (A253220)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-alpha Fodrin Antibody [SPTAN1/3351]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.