Recombinant Anti-CTLA4 Anticorps [CTLA4/6867R] (A314829)

Anti-CTLA4 Antibody [CTLA4/6867R]

Recombinant rabbit monoclonal [CTLA4/6867R] antibody to CTLA4.

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigenpresenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment. In particular, CTLA-4 down-modulates CD4+ helper T-cell activity and enhances Treg immunosuppressive functions. CTLA-4 has been shown to play a role in human diseases. CTLA-4 acts as a physiological brake on the activated immune system in order to maintain immune homeostasis. Several suppressive mechanisms for T-cell functions have been attributed to CTLA-4.

IHC-P

Jurkat or Raji cells. Lymph node or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human CTLA4. The exact sequence is proprietary.

Rabbit

Monoclonal

CTLA4/6867R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

30-43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ALPS5, CD, CD 152, CD152, CD152 antigen, CD152 isoform, Celiac disease 3, CELIAC3, CTLA 4, CTLA-4, CTLA4_HUMAN, Cytotoxic T cell associated 4, Cytotoxic T lymphocyte antigen 4, Cytotoxic T lymphocyte associated 4, Cytotoxic T lymphocyte associated 4, soluble isoform, included, Cytotoxic T lymphocyte associated antigen 4, Cytotoxic T lymphocyte associated antigen 4 short spliced form, Cytotoxic T lymphocyte associated protein 4, Cytotoxic T lymphocyte associated serine esterase 4, Cytotoxic T lymphocyte protein 4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, GRD4, GSE, ICOS, IDDM12, insulin-dependent diabetes mellitus 12, Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4, OTTHUMP00000216623