Anti-Cystatin C Anticorps [E01-8H8] (Biotin) (A280286)

$420

Anticorps monoclonal [E01-8H8] de souris contre Cystatin C (Biotin) pour ELISA.

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Cystatin C Antibody [E01-8H8] (Biotin)
Description du produit
Mouse monoclonal [E01-8H8] antibody to Cystatin C (Biotin).
Spécificité
This antibody recognises cystatin C, a small non-glycosylated 13.3 kDa basic cysteine inhibitor and a member of the Cystatin superfamily. Cystatin C is widely expressed in all nucleated cells in the body. It is also secreted from cells into circulation and other biological fluids including urine, seminal fluid, saliva and cerebrospinal fluid. Cystatin C specifically inhibits cysteine proteases such as papain, legumain and the cathepsins B, H, K, L and S. Through the regulation of cysteine proteases, it plays a role in various biological processes including immune responses, protein turnover, phatocytosis, antigen presentation and apoptosis. When released into the blood, cystatin C is filtered by the glomerous and metabolised by proximal tubular cells. Because of this filtration of cystatin C by the kidneys, this inhibitor is commonly used clinically as a biomarker of kidney function. Within immunological processes, cystatin C regulates proteolytic processing of pro-granzymes, MHC II antigen presentation and maturation of dendritic cells. Cystatin C is encoded by the gene CST3 and mutations of this gene are responsible for the heritable disease, cerebral amyloid angiopathy. The biotinylated Mouse anti Human cystatin C antibody, clone E01-8H8 (MCA6227B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human cystatin C antibody, clone B01-8B1 (MCA6226GA) as the capture antibody.
Applications
ELISA
Recommander des dilutions
ELISA: 1 µg/ml
Reactivité
Human
Immunogène
E. coli derived recombinant human full length cystatin C (Ser27-Ala146).
Hôte
Mouse
Clonalité
Monoclonal
Clone
E01-8H8
Isotype
IgG1
Conjuguer

Biotin

Purification
Protein G affinity chromatography of tissue culture supernatant.
Concentration
100 µg/ml
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.
Notes générales
Mouse anti Human cystatin C antibody, clone E01-8H8 , recognizes cystatin C, a small non-glycosylated 13.3 kDa basic cysteine inhibitor and a member of the Cystatin superfamily. Cystatin C is widely expressed in all nucleated cells in the body. It is also secreted from cells into circulation and other biological fluids including urine, seminal fluid, saliva and cerebrospinal fluid (Mussap & Plebani 2004). Cystatin C specifically inhibits cysteine proteases such as papain, legumain and the cathepsins B, H, K, L and S. Through the regulation of cysteine proteases, it plays a role in various biological processes including immune responses, protein turnover, phatocytosis, antigen presentation and apoptosis (Zi & Xu 2018). When released into the blood, cystatin C is filtered by the glomerous and metabolised by proximal tubular cells. Because of this filtration of cystatin C by the kidneys, this inhibitor is commonly used clinically as a biomarker of kidney function. (Zi & Xu 2018). Within immunological processes, cystatin C regulates proteolytic processing of pro-granzymes, MHC II antigen presentation and maturation of dendritic cells (Pierre & Mellman 1998). Cystatin C is encoded by the gene CST3 and mutations of this gene are responsible for the heritable disease, cerebral amyloid angiopathy (Jurczak et al. 2016).The biotinylated Mouse anti Human cystatin C antibody, clone E01-8H8 (MCA6227B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human cystatin C antibody, clone B01-8B1 (MCA6226GA) as the capture antibody.
Synonymes
AD 8, AD8, Amyloid angiopathy and cerebral hemorrhage, ARMD11, bA218C14.4, bA218C14.4 (cystatin C), Cst 3, Cst3, CST3 protein, Cystatin 3, Cystatin-3, Cystatin-C, Cystatin3, CystatinC, CYTC_HUMAN, Epididymis secretory protein Li 2, Gamma trace, Gamma-trace, HCCAA, HEL S 2, MGC117328, Neuroendocrine basic polypeptide, Post gamma globulin, Post-gamma-globulin
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.
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