This antibody recognises human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK.

Applications

Recommander des dilutions

WB: 1:500

Reactivité

Human

Immunogène

A peptide corresponding to amino acids 42-56 of human DR6 precursor.

Séquence

QPEQKASNLIGTYRH

Hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Conjuguer

Unconjugated

Concentration

500 µg/ml

Forme du produit

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Stockage

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Notes générales

Rabbit anti Human DR6 antibody recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Pan et al. 1998).

Synonymes

BM 018, BM018, CD358, Death receptor 6, DR 6, MGC31965, OTTHUMP00000039915, TNFR related death receptor 6, TNFRSF 21, TNFRSF21, TNFRSF21 protein, TNR21_HUMAN, Tumor necrosis factor receptor superfamily member 21, Tumor necrosis factor receptor superfamily member 21 precursor

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.