Anti-Factor VIII Anticorps [RFF-VIIIC/5] (A281667)

$480

Anticorps monoclonal [RFF-VIIIC/5] de souris contre Factor VIII pour WB, ELISA et RIA.

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Factor VIII Antibody [RFF-VIIIC/5]
Description du produit
Mouse monoclonal [RFF-VIIIC/5] antibody to Factor VIII.
Spécificité
This antibody recognises human Factor VIII, an essential blood coagulation factor. Factor VIII is primarily synthesized in the liver and is secreted into the bloodstream where it forms a complex with von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which in turn activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A (HEMA), a disorder characterised by the body’s inability to control blood clotting, potentially resulting in severe blood loss, even with minor injuries. recognises an epitope towards the C-terminus of full-length Factor VIII. It also recognises the ~80 kDa and ~70 kDa cleavage products.
Applications
WB, ELISA, RIA
Recommander des dilutions
ELISA: 1:400 - 1:4,000
Reactivité
Human
Immunogène
Affinity purified human Factor VIII.
Hôte
Mouse
Clonalité
Monoclonal
Clone
RFF-VIIIC/5
Isotype
IgG1
Conjuguer

Unconjugated

Purification
Protein G affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes human Factor VIII, an essential blood coagulation factor. Factor VIII is primarily synthesized in the liver and is secreted into the bloodstream where it forms a complex with von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which in turn activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A (HEMA), a disorder characterised by the body’s inability to control blood clotting, potentially resulting in severe blood loss, even with minor injuries. Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes an epitope towards the C-terminus of full-length Factor VIII. It also recognizes the ~80 kDa and ~70 kDa cleavage products.
Synonymes
AHF, Antihemophilic factor, Coagulation factor VIII, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, DXS1253E, F8, F8b, F8c, FA8_HUMAN, factor VIII F8B, Factor VIIIa light chain, FactorVIII, FVIII, Hema, Hemophilia A, Hemophilia, classic, OTTHUMP00000061446, OTTHUMP00000196174, Procoagulant component
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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