Anti-Fas Anticorps [FAS/3112] (A252200)

Name: Anti-Fas Antibody [FAS/3112] - BSA and Azide free
Brand: Antibodies.com
SKU: A252200
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [FAS/3112] de souris contre Fas pour ELISA et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique Plasma Membrane Marker

Spécifications

Nom du produit

Anti-Fas Antibody [FAS/3112] - BSA and Azide free

Description du produit

Mouse monoclonal [FAS/3112] antibody to Fas.

Spécificité

This antibody specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Applications

ELISA, IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 26-96, of human CD95 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

FAS/3112

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Masse moléculaire

38-50 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Fas Antibody [FAS/3112] (A249020).

Synonymes

ALPS 1A, ALPS1A, APO 1, Apo 1 antigen, APO 1 cell surface antigen, Apo-1 antigen, APO1, Apo1 antigen, APO1 cell surface antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, APT 1, APT1, CD 95, CD 95 antigen, CD95, CD95 antigen , Delta Fas, Delta Fas/APO 1/CD95, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), FAS 1, FAS 827dupA, Fas AMA, FAS Antigen, Fas cell surface death receptor, FAS1, FASLG receptor, FASTM, sFAS, Surface antigen APO1, TNF receptor superfamily, member 6, TNFRSF 6, TNFRSF6, TNR6_HUMAN, Tumor necrosis factor receptor superfamily member 6

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 2: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 3: SDS-PAGE - Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200)

SDS-PAGE analysis of Anti-Fas Antibody [FAS/3112] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Fas Antibody [FAS/3112]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.