Anti-Fas Ligand Anticorps [10F2] (A278948)

Anti-Fas Ligand Antibody [10F2] - BSA and Azide free

Mouse monoclonal [10F2] antibody to Fas Ligand.

This antibody recognises the human CD178 cell surface antigen, a ~40 kDa glycoprotein also known as Fas ligand (CD95L).CD178 is a member of the TNF family, which is expressed by activated T lymphocytes and NK cells. The protein may exist as either a membrane bound or a cleaved soluble form. CD178 plays an important role in T cell development and cytotoxicity. Binding of CD178 to Fas (CD95) results in the induction of apoptosis. Mouse anti Human CD178 antibody, clone 10F2 is reported to block the activity of Fas ligand.

Flow Cytometry, ELISA, IP, Functional Assays

Flow Cytometry: 1:25 - 1:50, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl

Human

Mouse

Monoclonal

10F2

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD178 antibody, clone 10F2 recognizes the human CD178 cell surface antigen, a ~40 kDa glycoprotein also known as Fas ligand (CD95L).CD178 is a member of the TNF family, which is expressed by activated T lymphocytes and NK cells. The protein may exist as either a membrane bound or a cleaved soluble form. CD178 plays an important role in T cell development and cytotoxicity. Binding of CD178 to Fas (CD95) results in the induction of apoptosis. Mouse anti Human CD178 antibody, clone 10F2 is reported to block the activity of Fas ligand (Legembre et al. 2002).

ALPS1B, Apoptosis (APO 1) antigen ligand 1, Apoptosis antigen ligand, Apoptosis antigen ligand 1, APT1LG1, APTL, CD178, CD178 antigen, CD95 L, CD95 ligand, CD95-L, CD95L, CD95L protein, Fas antigen ligand, Fas L, Fas ligand (TNF superfamily member 6), FASL, Fasl Fas ligand (TNF superfamily member 6), FASLG, Generalized lymphoproliferative disease, Gld, soluble form, TNF superfamily member 6, TNFL6_HUMAN, TNFSF6, Tumor necrosis factor (ligand) superfamily member 6, Tumor necrosis factor ligand superfamily member 6