Anti-HDAC6 Anticorps [PCRP-HDAC6-1A4] (A278111)

Anticorps monoclonal [PCRP-HDAC6-1A4] de souris contre HDAC6 pour IP, Flow Cytometry et IF.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-HDAC6 Antibody [PCRP-HDAC6-1A4] - BSA and Azide free
Description du produit
Mouse monoclonal [PCRP-HDAC6-1A4] antibody to HDAC6.
Spécificité
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.This enzyme deacetylates lysine residues in histones H2A, H2B, H3 and H4.
Applications
IP, Flow Cytometry, IF
Recommander des dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human HDAC6 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-HDAC6-1A4
Isotype
IgG2a
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
160 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-HDAC6 Antibody [PCRP-HDAC6-1A4] (A277523).
Synonymes
CPBHM, FLJ16239, HD 6, HD6, HDAC 6, HDAC6_HUMAN, Histone deacetylase 6, Histone deacetylase 6 (HD6), JM 21, JM21, KIAA0901, OTTHUMP00000032398, OTTHUMP00000197663, PPP1R90, Protein phosphatase 1 regulatory subunit 90
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Produits alternatifs à Anti-HDAC6 Anticorps [PCRP-HDAC6-1A4] (A278111)

Haut