Anti-LAG-3 Anticorps [LAG3/7380] (A316615)

$765

Anticorps monoclonal [LAG3/7380] de souris contre LAG-3 pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-LAG-3 Antibody [LAG3/7380] - BSA and Azide free
Description du produit
Mouse monoclonal [LAG3/7380] antibody to LAG-3.
Spécificité
LAG-3 (also called CD223) is a high affinity MHC class II ligand present on the surface of CD4+CD8+ T cells and NK cell, with shared homology in structure to CD4 molecules. It has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian, parasitic, and bacterial proteins that may influence a conserved biological function. LAG-3+CD4+CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro. LAG-3 inhibits CD4-dependent T cell function via its cytoplasmic domain. LAG-3 Lys-468 within a conserved KIEELE motif is essential for interaction with downstream signaling molecules. Furthermore, as a checkpoint inhibitor target, it may be superior to CTLA-4 and PD-1 since both antibodies only activate effector T-cells, whereas an antagonist LAG-3 antibody can both activate T effector cells (by downregulating the LAG-3 inhibiting signal into pre-activated LAG-3+ cells) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
Applications
IHC-P
Contrôle positif
Human tonsil or Hodgkin s lymphoma (IHC-P).
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 300-500) of human LAG3 protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
LAG3/7380
Isotype
IgG1
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
70 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
CD223, CD223 antigen, FDC protein, Lag3, LAG3_HUMAN, Lymphocyte activating 3, Lymphocyte Activation Gene 3, Lymphocyte activation gene 3 protein, Protein FDC
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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