Spécificité
In western blotting, this antibody detects an antigen of 125kDa in human liver and 135kDa in tumors of histiocytic origin. Its antigen in all macrophage types studied is located on the plasma membrane and within cytoplasmic structures including lysosomes. This antibody shows a restricted reactivity to cells of the monocyte/macrophage system. It specifically reacts with blood monocytes and stains resident macrophages in a wide variety of human tissues. This antibody does not stain antigen-presenting cells, i.e. Langerhans cells, and reportedly, its reactivity is restricted to histiocytes and macrophages.