Anti-Maspin Anticorps [SERPINB5/4975] (A277745)

Name: Anti-Maspin Antibody [SERPINB5/4975]
Brand: Antibodies.com
SKU: A277745
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [SERPINB5/4975] de souris contre Maspin pour WB et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-Maspin Antibody [SERPINB5/4975]

Description du produit

Mouse monoclonal [SERPINB5/4975] antibody to Maspin.

Spécificité

Maspin is structurally a serine protease inhibitor (serpin) that was initially isolated from normal human mammary epithelial cells. Serpins are a family of proteins that inhibit Chymotrypsin-like serine proteinases. Serpins control activated proteinases and several are involved in the regulation of cell death. Maspin is found in the extracellular matrix and at the plasma membrane. Maspin has been shown to act at the cell surface to block cell motility and inhibit invasion of breast and prostate cancer cells. Maspin is present in normal mammary epithelial cells but is absent in many tumor cell lines, yet no major structural alterations of the Maspin gene have been identified in tumor cells. Similarly, Maspin is expressed in normal prostate cells and downregulated or absent in prostate tumor cells.

Applications

WB, IHC-P

Recommander des dilutions

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 1-200, of human Maspin protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

SERPINB5/4975

Isotype

IgG1

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

42 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Maspin Antibody [SERPINB5/4975] - BSA and Azide free (A278333).

Synonymes

Ovalbumin, Peptidase inhibitor 5, PI-5, PI5, Protease inhibitor 5, protease inhibitor 5 (maspin), Serine (or cysteine) peptidase inhibitor, clade B, member 5, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5, Serpin B5, serpin family B member 5, Serpin peptidase inhibitor, Serpin peptidase inhibitor, clade B (ovalbumin), member 5, Serpinb5, SPB5_HUMAN, Spi5, Spi7

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Immunohistochemistry - Anti-Maspin Antibody [SERPINB5/4975] (A277745)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human skin tissue using Anti-Maspin Antibody [SERPINB5/4975]. Inset: PBS instead of the primary antibody. Secondary antibody negative control.

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Figure 2: Immunohistochemistry - Anti-Maspin Antibody [SERPINB5/4975] (A277745)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cervical squamous cell carcinoma using Anti-Maspin Antibody [SERPINB5/4975].

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Figure 3: Western Blot - Anti-Maspin Antibody [SERPINB5/4975] (A277745)

Western blot analysis of PC3 cell line lysate using Anti-Maspin Antibody [SERPINB5/4975].

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Figure 4: Anti-Maspin Antibody [SERPINB5/4975] (A277745)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Maspin Antibody [SERPINB5/4975]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.