Anti-Mast Cell Tryptase Anticorps [TPSAB1/1961] (A250206)

Anti-Mast Cell Tryptase Antibody [TPSAB1/1961]

Mouse monoclonal [TPSAB1/1961] antibody to Mast Cell Tryptase.

Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 115-223, of human Tryptase protein. The exact sequence is proprietary.

Mouse

Monoclonal

TPSAB1/1961

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

31-36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free (A253386).

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