Anti-MED7 Anticorps [PCRP-MED7-1B8] (A277851)

Anticorps monoclonal [PCRP-MED7-1B8] de souris contre MED7 pour ELISA, Flow Cytometry, IF et IP.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-MED7 Antibody [PCRP-MED7-1B8]
Description du produit
Mouse monoclonal [PCRP-MED7-1B8] antibody to MED7.
Spécificité
MED7, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
Applications
ELISA, Flow Cytometry, IF, IP
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins
Reactivité
Human
Immunogène
Recombinant full-length human MED7 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-MED7-1B8
Isotype
IgG2b
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
27.2 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MED7 Antibody [PCRP-MED7-1B8] - BSA and Azide free (A278439).
Synonymes
Activator recruited cofactor 34 kDa component, Activator-recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation subunit 9, Cofactor required for Sp1 transcriptional activation, subunit 9 (33kD), Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, CRSP complex subunit 9, CRSP33, CRSP9, hMED7, MED7_HUMAN, Mediator complex subunit 7, Mediator of RNA polymerase II transcription subunit 7, MGC12284, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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