Anti-MIF Anticorps [MIF/3488] (A277706)

Name: Anti-MIF Antibody [MIF/3488]
Brand: Antibodies.com
SKU: A277706
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [MIF/3488] de souris contre MIF pour WB et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-MIF Antibody [MIF/3488]

Description du produit

Mouse monoclonal [MIF/3488] antibody to MIF.

Spécificité

Macrophage migration inhibitory factor, known as MIF or glycosylationinhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor Î± (TNFÎ±), interleukin-1 (IL-1) and interferon-Î³ (IFN-Î³). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.

Applications

WB, IHC-P

Recommander des dilutions

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment corresponding to human MIF protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

MIF/3488

Isotype

IgG2a

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

13 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MIF Antibody [MIF/3488] - BSA and Azide free (A278294).

Synonymes

GIF, GLIF, Glycosylation inhibiting factor, Glycosylation-inhibiting factor, L-dopachrome isomerase, L-dopachrome tautomerase, Macrophage migration inhibitory factor, Macrophage migration inhibitory factor (glycosylation-inhibiting factor), MIF protein, MIF_HUMAN, MMIF, Phenylpyruvate tautomerase

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Immunohistochemistry - Anti-MIF Antibody [MIF/3488] (A277706)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue using Anti-MIF Antibody [MIF/3488]. Inset: PBS instead of the primary antibody. Secondary antibody negative control.

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Figure 2: SDS-PAGE - Anti-MIF Antibody [MIF/3488] (A277706)

SDS-PAGE analysis of Anti-MIF Antibody [MIF/3488] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 3: Western Blot - Anti-MIF Antibody [MIF/3488] (A277706)

Western blot analysis of (Lane 1) LNCaP cell line lysate and (Lane 2) PC3 cell line lysate using Anti-MIF Antibody [MIF/3488].

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Figure 4: Anti-MIF Antibody [MIF/3488] (A277706)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-MIF Antibody [MIF/3488]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.