Anti-NeuroG3 Anticorps [PCRP-NEUROG3-1E10] (A277730)

Anticorps monoclonal [PCRP-NEUROG3-1E10] de souris contre NeuroG3 pour ELISA, IP et Flow Cytometry.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-NeuroG3 Antibody [PCRP-NEUROG3-1E10]
Description du produit
Mouse monoclonal [PCRP-NEUROG3-1E10] antibody to NeuroG3.
Spécificité
This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1.The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.
Applications
ELISA, IP, Flow Cytometry
Recommander des dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells
Reactivité
Human
Immunogène
Recombinant full-length human NeuroG3 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-NEUROG3-1E10
Isotype
IgG2b
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
23.54 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-NeuroG3 Antibody [PCRP-NEUROG3-1E10] - BSA and Azide free (A278318).
Synonymes
ATH4B, Atoh5, bHLHa7, Class A basic helix-loop-helix protein 7, Math4B, Neurogenin-3, Neurogenin3, NGN-3, ngn3, NGN3_HUMAN, OTTHUMP00000019730, Protein atonal homolog 5
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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