Adiponectin Receptor 1 est un gène codé par le symbole ADIPOR1. D'autres noms incluent: Adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I; ADIPOR1; PAQR1; TESBP1A. Adiponectin Receptor 1 a une masse de 42.62kDa et une longueur d'acide aminé de 375.
Nous proposons 7 Adiponectin Receptor 1 kits ELISA pour la détection qualitative ou quantitative de Adiponectin Receptor 1 à partir d'échantillons Humain, Souris, Rat et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Résumé Entrez
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.
Spécificité tissulaire
Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
Similitudes de séquence
Belongs to the ADIPOR family.
Localisation cellulaire
Cell membrane.
Localized to the cell membrane and intracellular organelles.
