AMCase est un gène codé par le symbole CHIA. D'autres noms incluent: Acidic mammalian chitinase; Lung-specific protein TSA1902; CHIA. AMCase a une masse de 52.27kDa et une longueur d'acide aminé de 476.
Nous proposons 3 AMCase kits ELISA pour la détection qualitative ou quantitative de AMCase à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Résumé Entrez
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene.
Spécificité tissulaire
Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
Similitudes de séquence
Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
Localisation cellulaire
Secreted.
Secretion depends on EGFR activity.
