Amphiregulin est un gène codé par le symbole AREG. D'autres noms incluent: AR; Colorectum cell-derived growth factor; CRDGF; AREG; AREGB; SDGF. Amphiregulin a une masse de 27.9kDa et une longueur d'acide aminé de 252.
Nous proposons 10 Amphiregulin kits ELISA pour la détection qualitative ou quantitative de Amphiregulin à partir d'échantillons Humain, Souris, Rat, Bovin et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Résumé Entrez
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.
Similitudes de séquence
Belongs to the amphiregulin family.
Localisation cellulaire
Membrane.
