Angiogenin est un gène codé par le symbole ANG. D'autres noms incluent: Ribonuclease 5; RNase 5; ANG; RNASE5. Angiogenin a une masse de 16.55kDa, une longueur d'acide aminé de 147, et est impliqué dans Amyotrophic lateral sclerosis 9.
Nous proposons 15 Angiogenin kits ELISA pour la détection qualitative ou quantitative de Angiogenin à partir d'échantillons Humain, Souris, Rat, Bovin et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Résumé Entrez
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
Spécificité tissulaire
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Implication dans la maladie
Amyotrophic lateral sclerosis 9: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Similitudes de séquence
Belongs to the pancreatic ribonuclease family.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle lumen. Secreted. Nucleus. Nucleus > Nucleolus.
Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708).
