Angiopoietin 2 est un gène codé par le symbole ANGPT2. D'autres noms incluent: Angiopoietin-2; ANG-2; ANGPT2. Angiopoietin 2 a une masse de 56.92kDa et une longueur d'acide aminé de 496.
Nous proposons 9 Angiopoietin 2 kits ELISA pour la détection qualitative ou quantitative de Angiopoietin 2 à partir d'échantillons Humain, Souris, Rat, Porcin et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Résumé Entrez
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Localisation cellulaire
Secreted.
