Cathepsin L est un gène codé par le symbole CTSL. D'autres noms incluent: Cathepsin L1; Major excreted protein; MEP; CTSL; CTSL1. Cathepsin L a une masse de 37.56kDa et une longueur d'acide aminé de 333.
Nous proposons 5 Cathepsin L kits ELISA pour la détection qualitative ou quantitative de Cathepsin L à partir d'échantillons Humain, Souris, Rat, Bovin et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity).
Résumé Entrez
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
Similitudes de séquence
Belongs to the peptidase C1 family.
Localisation cellulaire
Lysosome. Apical cell membrane.
Localizes to the apical membrane of thyroid epithelial cells.
