CD137 est un gène codé par le symbole TNFRSF9. D'autres noms incluent: Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNFRSF9; ILA. CD137 a une masse de 27.9kDa et une longueur d'acide aminé de 255.
Nous proposons 5 CD137 kits ELISA pour la détection qualitative ou quantitative de CD137 à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Résumé Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Spécificité tissulaire
Expressed on the surface of activated T-cells.
Localisation cellulaire
Membrane.
