CNTF est un gène codé par le symbole CNTF. Il est également connu sous le nom de Ciliary neurotrophic factor. CNTF a une masse de 22.93kDa et une longueur d'acide aminé de 200.
Nous proposons 17 CNTF kits ELISA pour la détection qualitative ou quantitative de CNTF à partir d'échantillons Humain, Souris, Rat, Porcin, Lapin et Poulet.
Informations sur les Gènes et les Protéines
Résumé UniProt
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Résumé Entrez
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Spécificité tissulaire
Nervous system.
Similitudes de séquence
Belongs to the CNTF family.
Localisation cellulaire
Cytoplasm.
