Dermcidin est un gène codé par le symbole DCD. D'autres noms incluent: Preproteolysin; DCD; AIDD; DSEP. Dermcidin a une masse de 11.28kDa et une longueur d'acide aminé de 110.
Nous proposons 3 Dermcidin kits ELISA pour la détection qualitative ou quantitative de Dermcidin à partir d'échantillons Humain et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).
Résumé Entrez
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécificité tissulaire
Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
Localisation cellulaire
Secreted.
