FGF9 est un gène codé par le symbole FGF9. D'autres noms incluent: Fibroblast growth factor 9; FGF-9; Glia-activating factor; GAF; Heparin-binding growth factor 9; HBGF-9. FGF9 a une masse de 23.44kDa, une longueur d'acide aminé de 208, et est impliqué dans Multiple synostoses syndrome 3.
Nous proposons 8 FGF9 kits ELISA pour la détection qualitative ou quantitative de FGF9 à partir d'échantillons Humain, Souris, Rat, Bovin et Poulet.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Résumé Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.
Spécificité tissulaire
Glial cells.
Implication dans la maladie
Multiple synostoses syndrome 3: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism.
Similitudes de séquence
Belongs to the heparin-binding growth factors family.
Modification post-traductionnelle
Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
Localisation cellulaire
Secreted.
