IL15 est un gène codé par le symbole IL15. Communément appelé aussi: Interleukin-15; IL-15. IL15 a une masse de 18.09kDa et une longueur d'acide aminé de 162.
Nous proposons 26 IL15 kits ELISA pour la détection qualitative ou quantitative de IL15 à partir d'échantillons Humain, Souris, Rat, Bovin, Porcin, Lapin, Poulet, Canin et Cochon d'Inde.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).
Résumé Entrez
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Spécificité tissulaire
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Similitudes de séquence
Belongs to the IL-15/IL-21 family.
Localisation cellulaire
Secreted.
