IL17C est un gène codé par le symbole IL17C. Communément appelé aussi: Interleukin-17C; IL-17C; Cytokine CX2. IL17C a une masse de 21.77kDa et une longueur d'acide aminé de 197.
Nous proposons 2 IL17C kits ELISA pour la détection qualitative ou quantitative de IL17C à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Résumé Entrez
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells.
Similitudes de séquence
Belongs to the IL-17 family.
Localisation cellulaire
Secreted.
