IL18 est un gène codé par le symbole IL18. Communément appelé aussi: Interleukin-18; IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; IGIF; IL1F4. IL18 a une masse de 22.33kDa et une longueur d'acide aminé de 193.
Nous proposons 25 IL18 kits ELISA pour la détection qualitative ou quantitative de IL18 à partir d'échantillons Humain, Souris, Rat, Bovin, Porcin, Lapin, Poulet, Canin, Goat et Cochon d'Inde.
Informations sur les Gènes et les Protéines
Résumé UniProt
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
Résumé Entrez
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Similitudes de séquence
Belongs to the IL-1 family.
Modification post-traductionnelle
The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
Localisation cellulaire
Secreted.
