Interleukin 34 est un gène codé par le symbole IL34. Communément appelé aussi: Interleukin-34; IL-34; IL34; C16orf77. Interleukin 34 a une masse de 27.48kDa et une longueur d'acide aminé de 242.
Nous proposons 10 Interleukin 34 kits ELISA pour la détection qualitative ou quantitative de Interleukin 34 à partir d'échantillons Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Résumé Entrez
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008
Spécificité tissulaire
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Similitudes de séquence
Belongs to the IL-34 family.
Localisation cellulaire
Secreted.
