LBP est un gène codé par le symbole LBP. Il est également connu sous le nom de Lipopolysaccharide-binding protein. LBP a une masse de 53.38kDa et une longueur d'acide aminé de 481.
Nous proposons 11 LBP kits ELISA pour la détection qualitative ou quantitative de LBP à partir d'échantillons Humain, Souris, Rat, Bovin et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).
Résumé Entrez
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).
Spécificité tissulaire
Detected in blood serum (at protein level).
Similitudes de séquence
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Localisation cellulaire
Secreted. Cytoplasmic granule membrane.
Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
