Macrophage inflammatory protein 5 est un gène codé par le symbole CCL15. Communément appelé aussi: C-C motif chemokine 15; Chemokine CC-2; HCC-2; Leukotactin-1; LKN-1; MIP-1 delta; MIP-5; Mrp-2b; NCC-3; Small-inducible cytokine A15; CCL15; MIP5; NCC3; SCYA15. Macrophage inflammatory protein 5 a une masse de 12.25kDa et une longueur d'acide aminé de 113.
Nous proposons 1 Macrophage inflammatory protein 5 kits ELISA pour la détection qualitative ou quantitative de Macrophage inflammatory protein 5 à partir d'échantillons Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Résumé Entrez
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14).
Spécificité tissulaire
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Localisation cellulaire
Secreted.
