Milk Fat Globule 1 est un gène codé par le symbole MFGE8. Communément appelé aussi: Lactadherin; Breast epithelial antigen BA46; HMFG; MFGM; Milk fat globule-EGF factor 8; MFG-E8; SED1; MFGE8. Milk Fat Globule 1 a une masse de 43.11kDa et une longueur d'acide aminé de 387.
Nous proposons 3 Milk Fat Globule 1 kits ELISA pour la détection qualitative ou quantitative de Milk Fat Globule 1 à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Résumé Entrez
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Modification post-traductionnelle
Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
Localisation cellulaire
Membrane. Secreted.
