Pepsinogen II est un gène codé par le symbole PGC. Communément appelé aussi: Gastricsin; Pepsinogen C; PGC. Pepsinogen II a une masse de 42.43kDa et une longueur d'acide aminé de 388.
Nous proposons 5 Pepsinogen II kits ELISA pour la détection qualitative ou quantitative de Pepsinogen II à partir d'échantillons Humain, Souris, Rat et Poulet.
Informations sur les Gènes et les Protéines
Résumé UniProt
Hydrolyzes a variety of proteins.
Résumé Entrez
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Similitudes de séquence
Belongs to the peptidase A1 family.
Localisation cellulaire
Secreted.
