SERPINB4 est un gène codé par le symbole SERPINB4. Il est également connu sous le nom de: Serpin B4; Leupin; Peptidase inhibitor 11; PI-11; Squamous cell carcinoma antigen 2; SCCA-2; PI11; SCCA2. SERPINB4 a une masse de 44.85kDa et une longueur d'acide aminé de 390.
Nous proposons 2 SERPINB4 kits ELISA pour la détection qualitative ou quantitative de SERPINB4 à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Résumé Entrez
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation.
Spécificité tissulaire
Squamous cells.
Similitudes de séquence
Belongs to the serpin family. Ov-serpin subfamily.
Localisation cellulaire
Cytoplasm.
Seems to also be secreted in plasma by cancerous cells but at a low level.
