TECK est un gène codé par le symbole CCL25. Il est également connu sous le nom de: C-C motif chemokine 25; Chemokine Small-inducible cytokine A25; Thymus-expressed chemokine; CCL25; SCYA25. TECK a une masse de 16.61kDa et une longueur d'acide aminé de 150.
Nous proposons 5 TECK kits ELISA pour la détection qualitative ou quantitative de TECK à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Résumé Entrez
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Localisation cellulaire
Secreted.
