TGF alpha est un gène codé par le symbole TGFA. Il est également connu sous le nom de: Protransforming growth factor alpha; TGFA. TGF alpha a une masse de 17.01kDa et une longueur d'acide aminé de 160.
Nous proposons 15 TGF alpha kits ELISA pour la détection qualitative ou quantitative de TGF alpha à partir d'échantillons Humain, Souris, Rat, Porcin, Lapin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Résumé Entrez
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Localisation cellulaire
Secreted > Extracellular space.
