Thrombopoietin est un gène codé par le symbole THPO. Il est également connu sous le nom de: C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand; THPO. Thrombopoietin a une masse de 37.82kDa, une longueur d'acide aminé de 353, et est impliqué dans Thrombocythemia 1.
Nous proposons 12 Thrombopoietin kits ELISA pour la détection qualitative ou quantitative de Thrombopoietin à partir d'échantillons Humain, Souris, Rat, Bovin et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Résumé Entrez
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Implication dans la maladie
Thrombocythemia 1: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
Similitudes de séquence
Belongs to the EPO/TPO family.
Localisation cellulaire
Secreted.
