Tissue Factor Pathway Inhibitor est un gène codé par le symbole TFPI. Il est également connu sous le nom de: TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI; TFPI1. Tissue Factor Pathway Inhibitor a une masse de 35.02kDa et une longueur d'acide aminé de 304.
Nous proposons 4 Tissue Factor Pathway Inhibitor kits ELISA pour la détection qualitative ou quantitative de Tissue Factor Pathway Inhibitor à partir d'échantillons Humain, Souris, Rat et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Résumé Entrez
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Spécificité tissulaire
Mostly in endothelial cells.
Modification post-traductionnelle
O-glycosylated.
Localisation cellulaire
Secreted.
