VCAM1 est un gène codé par le symbole VCAM1. Il est également connu sous le nom de: Vascular cell adhesion protein 1; V-CAM 1; INCAM-100. VCAM1 a une masse de 81.28kDa et une longueur d'acide aminé de 739.
Nous proposons 12 VCAM1 kits ELISA pour la détection qualitative ou quantitative de VCAM1 à partir d'échantillons Humain, Souris, Rat, Porcin, Lapin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Résumé Entrez
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Spécificité tissulaire
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Modification post-traductionnelle
Sialoglycoprotein.
Localisation cellulaire
Membrane.
