ALDH1A1 est un gène codé par le symbole ALDH1A1. D'autres noms incluent: Retinal dehydrogenase 1; RALDH 1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALDC; ALDH1; PUMB1. ALDH1A1 a une masse de 54.86kDa et une longueur d'acide aminé de 501.
Nous proposons 22 des anticorps contre ALDH1A1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).
Résumé Entrez
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
Similitudes de séquence
Belongs to the aldehyde dehydrogenase family.
Modification post-traductionnelle
The N-terminus is blocked most probably by acetylation.
Localisation cellulaire
Cytoplasm > Cytosol.
