alpha Defensin 1 est un gène codé par le symbole DEFA1. D'autres noms incluent: Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; DEFA1; DEF1; DEFA2; MRS. alpha Defensin 1 a une masse de 10.2kDa et une longueur d'acide aminé de 94.
Nous proposons 6 des anticorps contre alpha Defensin 1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
Résumé Entrez
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Similitudes de séquence
Belongs to the alpha-defensin family.
Modification post-traductionnelle
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
Localisation cellulaire
Secreted.
