ARHGEF7 est un gène codé par le symbole ARHGEF7. D'autres noms incluent: Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB. ARHGEF7 a une masse de 90.01kDa et une longueur d'acide aminé de 803.
Nous proposons 10 des anticorps contre ARHGEF7, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Résumé Entrez
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
Modification post-traductionnelle
Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
Localisation cellulaire
Cell junction > Focal adhesion. Cell projection > Ruffle. Cytoplasm > Cell cortex. Cell projection > Lamellipodium.
Detected at cell adhesions. A small proportion is detected at focal adhesions.
