Bak est un gène codé par le symbole BAK1. D'autres noms incluent: Bcl-2 homologous antagonist/killer; Apoptosis regulator Bcl-2-like protein 7; Bcl2-L-71; BCL2L7; CDN1. Bak a une masse de 23.41kDa et une longueur d'acide aminé de 211.
Nous proposons 12 des anticorps contre Bak, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Résumé Entrez
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Spécificité tissulaire
Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Similitudes de séquence
Belongs to the Bcl-2 family.
Localisation cellulaire
Mitochondrion outer membrane.
